Tetrahedron Letters p. 3905 - 3908 (1994)
Update date:2022-08-04
Topics:
Jefford, Charles W.
Thornton, Steven R.
Sienkiewicz, Krzysztof
L-Glutamic diethyl ester hydrochloride was converted to its pyrrole derivative 22 by condensation with 2,5-dimethoxytetrahydrofuran in water.Cyclization of 22 with BBr3 afforded (5S)-5,6-dihydro-5-etoxycarbonyl-8(7H)-indolizinone (23).Catalytic hydrogenation of 23 over Pd/C in acetic acid gave exclusively (5S,9R)-5-ethoxycarbonylindolizidine in an overall yield of 41percent, whereas hydrogenation over Rh/Al2O3 in ethanol gave predominantly (5S,8S,9S)-5-ethoxycarbonyl-8-hydroxyindolizidine in 48.5percent overall yield.
View MoreContact:86-575-86132822，86-575-86085355
Address:No.418 Dadao West Road,Qixing Street,Xinchang, Zhejiang Province, China.
Contact:86-931-8272767
Address:Room 602, No.461, Nanchang Road, Chengguan District, Lanzhou City, China PRC
Contact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Zhengzhou Yuanli Biological Technology Co., Ltd.
Contact:+86-371-67897870/67897895
Address:No. 38, Qingyang Street, Zhengzhou, Henan, China
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Doi:10.1016/j.ejmech.2013.08.018
(2013)Doi:10.1080/00958972.2013.841902
(2013)Doi:10.1016/j.carres.2017.03.002
(2017)Doi:10.1016/S0040-4039(00)78752-1
(1980)Doi:10.1039/c19660000305
(1966)Doi:10.1016/S0040-4020(01)86352-3
(1993)
