Tetrahedron Letters p. 3905 - 3908 (1994)
Update date:2022-08-04
Topics:
Jefford, Charles W.
Thornton, Steven R.
Sienkiewicz, Krzysztof
L-Glutamic diethyl ester hydrochloride was converted to its pyrrole derivative 22 by condensation with 2,5-dimethoxytetrahydrofuran in water.Cyclization of 22 with BBr3 afforded (5S)-5,6-dihydro-5-etoxycarbonyl-8(7H)-indolizinone (23).Catalytic hydrogenation of 23 over Pd/C in acetic acid gave exclusively (5S,9R)-5-ethoxycarbonylindolizidine in an overall yield of 41percent, whereas hydrogenation over Rh/Al2O3 in ethanol gave predominantly (5S,8S,9S)-5-ethoxycarbonyl-8-hydroxyindolizidine in 48.5percent overall yield.
View MoreZhangJiaGang YaRui Chemical Co.,Ltd.
Contact:0512-58360968
Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
Chengdu Gelipu Biotechnology Co., Ltd.
website:http://www.glp-china.com
Contact:86-28-82610909
Address:chegndu
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
Contact:+86-535-8888888
Address:No.161 Haishi Rd.
shanghai hekang chemical co.ltd
Contact:021-54173790
Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
Doi:10.1016/j.ejmech.2013.08.018
(2013)Doi:10.1080/00958972.2013.841902
(2013)Doi:10.1016/j.carres.2017.03.002
(2017)Doi:10.1016/S0040-4039(00)78752-1
(1980)Doi:10.1039/c19660000305
(1966)Doi:10.1016/S0040-4020(01)86352-3
(1993)
