Tetrahedron Letters p. 1149 - 1152 (1994)
Update date:2022-08-03
Topics:
Cho
Johnson
The syntheses of the 5-(3-oxopropen-1-yl) derivatives of dU (5) and ddU (6) and their biological activity are reported. Good antiviral activity (EC50, 1.4 μg/mL) and selectivity (SI>71.4) is shown by 5 against VZV, whereas in the case of 6 the antiviral activity (EC50, 2.6 μg/mL; SI>38.5) against EBV is greater than that of Acyclovir (EC50, 9.3 μg/mL).
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Doi:10.1134/S1070363211090271
(2011)Doi:10.1039/c3cc48761j
(2014)Doi:10.1002/chem.201903754
(2020)Doi:10.1021/jm301708u
(2013)Doi:10.1039/jr9650000062
(1965)Doi:10.1080/00397919308011249
(1993)
