(E)-5-(3-oxopropen-1-yl)-2'-deoxyuridine and (E)-5-(3-oxopropen-1-yl)-2',3'-dideoxyuridine; new antiviral agents: Syntheses and biological activity

Article abstract of DOI:10.1016/0040-4039(94)88009-3

The syntheses of the 5-(3-oxopropen-1-yl) derivatives of dU (5) and ddU (6) and their biological activity are reported. Good antiviral activity (EC₅₀, 1.4 μg/mL) and selectivity (SI>71.4) is shown by 5 against VZV, whereas in the case of 6 the antiviral activity (EC₅₀, 2.6 μg/mL; SI>38.5) against EBV is greater than that of Acyclovir (EC₅₀, 9.3 μg/mL).