The synthesis of unusual tetrahydropyrimidine amino acids

Article abstract of DOI:10.1016/S0040-4039(00)60152-1

The synthesis of derivatives of 2-(1-an-aminoalkyl)-4-carboxy-3,4,5,6-tetrahydropyrimidines, unusual amino acids isolated from bacterial siderophores, is described, from condensation of N-protected amino acids imidates or thiomidates with 2,4-diaminobutyrylglycine methyl ester.