Journal of Heterocyclic Chemistry p. 1431 - 1436 (1993)
Update date:2022-08-05
Topics:
Dong Chin Kim
Won Hyung Yoon
Choi
Kim
A study directed toward the synthesis of saulatine (5,8,9,14a-tetrahydro- 3,4,11,12-tetramethoxy-isoquino[1,2-b]benzazepine-6,14-dione) is described. The successful synthetic route consists of three steps starting with 3,4- dimethoxyphenethylamine and 2-bromo-(3,4-dimethoxy-2- ethoxycarbomethylphenyl)-acetate. It was found that the methoxy moieties present on the aromatic rings prohibit the use of the intramolecular Friedel- Crafts reaction with a Lewis acid catalyst for ring construction because of their demethylation tendency under the reaction conditions.
View MoreAntaeus Bio-technology Co., LTD(expird)
Contact:021-31252569
Address:shanghai pudong
Shandong Topscience Biotech Co., Ltd.
Contact:0633-2619278
Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
Contact:86 513 85512619
Address:Rm.1306, Building A, Wenfeng Mansion,168 Gongnong Road, Nantong Jiangsu China
Contact:+86-025-52406782
Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
Contact:+86-10-83993285
Address:Rm.1708, Haobai Tower, Building 6, No.50, North Road, West Third Ring, Haidian District, Beijing, China
Doi:10.1166/jnn.2017.14076
(2017)Doi:10.1016/S0040-4020(01)81551-9
(1993)Doi:10.1016/S0277-5387(03)00132-3
(2003)Doi:10.1002/hlca.19670500602
(1967)Doi:10.1002/hlca.19930760809
(1993)Doi:10.1055/s-1994-25517
(1994)
