Journal of Heterocyclic Chemistry p. 1431 - 1436 (1993)
Update date:2022-08-05
Topics:
Dong Chin Kim
Won Hyung Yoon
Choi
Kim
A study directed toward the synthesis of saulatine (5,8,9,14a-tetrahydro- 3,4,11,12-tetramethoxy-isoquino[1,2-b]benzazepine-6,14-dione) is described. The successful synthetic route consists of three steps starting with 3,4- dimethoxyphenethylamine and 2-bromo-(3,4-dimethoxy-2- ethoxycarbomethylphenyl)-acetate. It was found that the methoxy moieties present on the aromatic rings prohibit the use of the intramolecular Friedel- Crafts reaction with a Lewis acid catalyst for ring construction because of their demethylation tendency under the reaction conditions.
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Doi:10.1166/jnn.2017.14076
(2017)Doi:10.1016/S0040-4020(01)81551-9
(1993)Doi:10.1016/S0277-5387(03)00132-3
(2003)Doi:10.1002/hlca.19670500602
(1967)Doi:10.1002/hlca.19930760809
(1993)Doi:10.1055/s-1994-25517
(1994)
