Asymmetric Synthesis of 1,1-Disubstituted Tetralins and Dihydronaphthalenes by Diastereoselective Addition of Lithiosilanes to Chiral Naphthalenes

Article abstract of DOI:10.1021/jo00084a007

Highly diastereoselective additions of lithiosilanes to chiral naphthalenes can be performed in ether/THF.Trapping of the resulting azaenolate, followed by protodesilylation, allows access to 1,1-disubstituted tetralins or dihydronaphthalenes in good yields and high enantiomeric excess.