Indoles X: Synthesis, structure and D2-affinity of the β-carboline-analogue of flutroline

Article abstract of DOI:10.1002/ardp.19933261206

10 is a β-carboline analogue of the neuroleptic flutroline(2a,b)) with significant lower affinity at the dopamine D₂ binding site. Various synthetic routes to 10 and the solid state structure of 8 are described, structure activity relations, in particular the importance of the 'S-shape' and the rigid dopamine conformation are discussed.