A novel and versatile silicon-derived linkage agent, 4-[1-hydroxy-2-(trimethylsilyl)ethyl]benzoic acid, compatible with the Fmoc/t-Bu strategy for solid-phase synthesis of C-terminal peptide acids

Article abstract of DOI:10.1021/ja00084a016

Tryptophan alkylation by resin-derived carbocations and formation of diketopiperazine are two major yield reducing side reactions observed in Fmoc/t-Bu based solid-phase peptide synthesis. With the development of a versatile silicon-based linkage agent, "