Isolation, Structure, and Synthesis of Dolastatin D, a Cytotoxic Cyclic Depsipeptide from the Sea Hare Dolabella auricularia

Article abstract of DOI:10.1016/S0040-4039(00)61356-4

Dolastatin D (1), a cytotoxic cyclic depsipeptide possessing the novel β-amino acid (2R,3R)-3-amino-2-methylbutanoic acid <(2R,3R)-3> as a component, has been isolated from the Japanese sea hare Dolabella auricularia.The absolute stereostructure of 1 was elucidated on the basis of spectroscopic analysis and chemical degradation and was further confirmed by synthesis.