Activity of diimidazoline amides against African trypanosomiasis

Article abstract of DOI:10.1016/j.bmcl.2013.12.064

We identified several diimidazoline mono- and diamides that were as potent as pentamidine against Trypanosoma brucei rhodesiense in vitro. All of these were also less cytotoxic than pentamidine, but none was as effective as the latter in a T. brucei rhode