The synthesis of pyrimidineisothiazolones. The effect of temperature on the addition of aryl amines to functionalized pyrimidines

DOI: 10.1016/S0040-4039(00)61393-X

Source and publish data:

Tetrahedron Letters p. 8213 - 8216 (1993)

Update date:2022-08-05

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Authors:

Decicco Decicco

Nelson Nelson

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Article abstract of DOI:10.1016/S0040-4039(00)61393-X

A new synthesis for the hither-to-unknown pyrimidine isothiazolones 1 and 2 is detailed. The low temperature selectivity of amine nucleophiles on 6-chloropyrimidine-5-acylbromides (12) for the acylbromide over the ring chloride provides a new procedure fo

Full text of DOI:10.1016/S0040-4039(00)61393-X

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