A Highly Diastereoselective Tandem Michael-Michael Addition Reaction in a Rotameric Ring System: Steric Acceleration due to Conformation Locking

DOI: 10.1016/S0040-4020(01)80175-7

Source and publish data:

Tetrahedron p. 9721 - 9734 (1993)

Update date:2022-08-03

Topics:

Authors:

Saito, Kenji

Yamamoto, Makoto

Yamada, Kazutoshi

Tagaki, Hideo

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Article abstract of DOI:10.1016/S0040-4020(01)80175-7

A highly diastereoselective one-pot tandem Michael-Michael addition reaction developed in a rotamerically locked conformation is described.Reaction of isocyanates 8 - 13 with hydroxylactone 14 gave tandem Michael-Michael adducts 22 - 26 in good to excelle

Full text of DOI:10.1016/S0040-4020(01)80175-7

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