A Highly Diastereoselective Tandem Michael-Michael Addition Reaction in a Rotameric Ring System: Steric Acceleration due to Conformation Locking

DOI: 10.1016/S0040-4020(01)80175-7

Source and publish data:

Tetrahedron p. 9721 - 9734 (1993)

Update date:2022-08-03

Topics:

Authors:

Saito, Kenji

Yamamoto, Makoto

Yamada, Kazutoshi

Tagaki, Hideo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)80175-7

A highly diastereoselective one-pot tandem Michael-Michael addition reaction developed in a rotamerically locked conformation is described.Reaction of isocyanates 8 - 13 with hydroxylactone 14 gave tandem Michael-Michael adducts 22 - 26 in good to excelle

Full text of DOI:10.1016/S0040-4020(01)80175-7

Products guided by the article

Product name:methyl (E)-2'-isocyanatocinnamate

Cas No:155710-64-8

R&D Labs maybe for 155710-64-8

Lanzhou huibang biological chemical technology Co., LTD

Contact:0931-7843964

Address:NO.2011,Yannan Road,Chengguan,
KangZhiYuan Pharmaceutical Company Limited

Contact:(Sabrina)86-20-85273232

Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Hangzhou TJM Chemical Trade Co., Ltd

Contact:86-571-88223276 86-13388481653

Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
Wuhan Fortuna Chemical Co.,Ltd

website:http://www.fortunachem.com

Contact:86-27-59207850

Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Yicheng Goto Pharmaceuticals Co.,Ltd.

Contact:+86 710 3423122

Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China

Relevant to this article

Reexamination of the bromination of 2-nitrobenzaldehyde with NBS or NaBr-NaIO₄ in sulfuric acid

Doi:10.1080/00397911.2013.838790
(2014)
Cyclometallated compounds of Pd(II) with pyrazole derivatives. Unusual double palladation of diarylbis(N-pyrazolyl)methanes

Doi:10.1016/0022-328X(94)87180-9
(1994)
CAL-B catalyzed desymmetrization of 3-alkylglutarate: "olefin effect" and asymmetric synthesis of pregabalin

Doi:10.1039/c3ob40311d
(2013)
Synthesis of a novel nitrone, 2-phenyl-5,5-dimethyl-1-pyrroline N-oxide (nitronyl-¹³C), for enhanced radical addend recognition and spin adduct persistence

Doi:10.1021/ja00088a009
(1994)
In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA

Doi:10.1016/j.ejmech.2013.11.042
(2014)
Studies on novel heterocyclic ring systems. Reactions of 2-[ p-(N,N'- dimethylaminophenyl)]-naphtho [2,1-b] 2,3-dihydropyran-4-one with 2- mercaptoaniline and formation of naphtho[2,1-b] pyrano [4,3-c] pyridazin-3- one derivative

Doi:10.1080/00397919408010215
(1994)

Article Doi