Stereoselective Phosphonylation of Aldehydes via Chiral Phosphordiamidites. A Potentially Versatile Asymmetric Route to Organophosphorus Biomolecules

DOI: 10.1039/c39940000743

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 743 - 744 (1994)

Update date:2022-07-29

Topics:

Authors:

Sum, Vivienne

Kee, Terence P.

Thornton-Pett, Mark

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39940000743

The novel, chiral phosphordiamidite, PN(SiMe3)2 containing deprotonated ephidrine has been shown to phosphonylate aldehydes readily to afford α-functionalised phosphonate esters with diastereoselectivities up to ca. 96percent.

Full text of DOI:10.1039/c39940000743

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:(2S,4S,5R)-2-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine

Cas No:155730-44-2

R&D Labs maybe for 155730-44-2

Jiangsu Zenji Pharmaceuticals LTD

Contact:+86-025-83172562; +1-224-888-1133(USA)

Address:No.5 Xinmofan Road
Cangzhou Senary Chemical Science-tech Co., Ltd

Contact:+86-317-3563899, 3563699

Address:168 Jinde Road, Cangzhou, Hebei, China
Yicheng Goto Pharmaceuticals Co.,Ltd.

Contact:+86 710 3423122

Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China
Suzhou Chenke Biotech Co., Ltd.

Contact:+86-18662408853

Address:NO.150, Renai Road, Suzhou Industrial Park
Shanghai Dynamic Industrial Co.,Ltd.

website:http://www.shdynamic.com

Contact:86-021 3392 6680

Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China

Relevant to this article

Stereoselective electrophile-induced mono- and bis-cyclisation-fragmentation reactions of alkenyl oxime O-allyl and O-benzyl ethers. Synthesis of dihydropinidine

Doi:10.1016/S0040-4020(01)01118-8
(2002)
Syntheses and exploration of new biological activities in ethyl 6/7-substituted and 6, 7-disubstituted quinolin-4-one-3-carboxylates

Doi:10.1016/0960-894X(95)00577-G
(1996)
Amelioration of the leaving group ability of the aryl sulfone moiety via intramolecular oxygen silylation

Doi:10.1021/ja00092a015
(1994)
SNAAP sulfonimidate alkylating agent for acids, alcohols, and phenols 1

Doi:10.1055/s-0033-1339921
(2013)
Synthesis and anticonvulsant activity of 8-alkoxy-5,6-dihydro-4Hbenzo[f][1, 2,4]triazolo[4,3-a]azepine derivatives

Doi:10.1007/s00044-011-9771-5
(2012)
Synthesis of quinazoin-4-ones through an acid ion exchange resin mediated cascade reaction

Doi:10.1039/d0ob00881h
(2020)

Article Doi