Stereoselective Phosphonylation of Aldehydes via Chiral Phosphordiamidites. A Potentially Versatile Asymmetric Route to Organophosphorus Biomolecules

DOI: 10.1039/c39940000743

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 743 - 744 (1994)

Update date:2022-07-29

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Authors:

Sum, Vivienne

Kee, Terence P.

Thornton-Pett, Mark

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Article abstract of DOI:10.1039/c39940000743

The novel, chiral phosphordiamidite, PN(SiMe3)2 containing deprotonated ephidrine has been shown to phosphonylate aldehydes readily to afford α-functionalised phosphonate esters with diastereoselectivities up to ca. 96percent.

Full text of DOI:10.1039/c39940000743

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