Identification of small-molecule inhibitors of Trypansoma cruzi replication

DOI: 10.1016/j.bmcl.2011.09.057

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 7197 - 7200 (2011)

Update date:2022-08-04

Topics:

Authors:

Germain, Andrew R.

Carmody, Leigh C.

Dockendorff, Chris

Galan-Rodriguez, Cristina

Rodriguez, Ana

Johnston, Stephen

Bittker, Joshua A.

MacPherson, Lawrence

Dandapani, Sivaraman

Palmer, Michelle

Schreiber, Stuart L.

Munoz, Benito

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2011.09.057

We report the outcome of a high-throughput small-molecule screen to identify novel, nontoxic, inhibitors of Trypansoma cruzi, as potential starting points for therapeutics to treat for both the acute and chronic stages of Chagas disease. Two compounds wer

Full text of DOI:10.1016/j.bmcl.2011.09.057

Products guided by the article

Product name:1-(3-chloro-benzyl)-piperidine-3-carboxylic acid diethylamide

Cas No:15575-79-8

R&D Labs maybe for 15575-79-8

Tianjin Crest Pharmaceutical R&D Co., Ltd. （Tianjin Yao Technology Development Co., Ltd.）(expird)

Contact:+86-22-66211386

Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Shanghai Dynamic Industrial Co.,Ltd.

website:http://www.shdynamic.com

Contact:86-021 3392 6680

Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.

website:http://www.zyterpharm.com

Contact:+86-18858184290

Address:West Wenyi Road, Cangqian, Yuhang
Ring Specialty Chemicals Inc.

Contact:+1-416-493-6870

Address:Toronto, Canada
Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Contact:+86-15853188990

Address:Huadian Pioneer Park, Huadian Township, Qihe County, Dezhou City, Shandong, P.R.China

Relevant to this article

An NMR study on the reaction of [(κ ²-P,N)-Ph ₂PCH₂CH₂NMe₂]PtMe₂ with activated chlorocarbons: C-Cl and C-C activation, followed by C-N cleavage of the phosphinoalkylamine ligand and formation of an ylide complex

Doi:10.1007/s00706-014-1158-0
(2014)
An effective method for the synthesis of carboxylic esters and lactones using substituted benzoic anhydrides with Lewis acid catalysts

Doi:10.1016/j.tet.2003.12.013
(2004)
1,3,2,4-Diazadiphosphetidines as ligand and base for palladium-catalyzed suzukimiyaura, sonogashirahagihara, and homocoupling reactions of aryl halides under heterogeneous conditions in water

Doi:10.1246/bcsj.20090299
(2010)
Selective anion sensing by chiral macrocyclic receptors with multiple hydrogen-bonding sites

Doi:10.1021/ol403643d
(2014)
Synthetic Studies of Venturicidins. Synthesis of the C1-C14 Segment of Venturicidins

Doi:10.1246/bcsj.66.3464
(1993)
Direct access to isoindolines through tandem Rh(III)-catalyzed alkenylation and cyclization of N-benzyltriflamides

Doi:10.1039/c3cc49486a
(2014)

Article Doi