The Desferrithiocin Pharmacophore

DOI: 10.1021/jm00036a005

Source and publish data:

Journal of Medicinal Chemistry p. 1411 - 1417 (1994)

Update date:2022-08-03

Topics:

Authors:

Bergeron, Raymond J.

Liu, Charles Z.

McManis, James S.

Xia, Michael X. B.

Algee, Samuel E.

Wiegand, Jan

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Article abstract of DOI:10.1021/jm00036a005

The (S)-desferrithiocin (DFT) skeleton is shown to be a useful pharmacophore on which to design orally effective iron chelators.While the study clearly indicates that formal reduction of the desazadesmethyldesferrithiocin thiazoline to a thiazolidine (6),

Full text of DOI:10.1021/jm00036a005

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