Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors

Article abstract of DOI:10.1021/jm00035a014

Aminopeptidase A (APA) and aminopeptidase N (APN) are two metallopeptidases which have been suggested to be involved in the enzymatic cascade of the renin-angiotensin system. APA liberates angotensin III from angiotensin II by releasing the N-terminal asp