Stereocontrolled synthesis of 2,3-diaminobutanoic acids

Article abstract of DOI:10.1016/S0040-4039(97)00158-5

A straightforward synthesis of 2,3-diaminobutanoic acids is reported. The synthesis is based on the nucleophilic addition of methylmagnesium bromide to differentially protected nitrones derived from L-serine. The change of the protecting groups in the starting nitrone is crucial for the stereocontrol of the reaction.