Tetrahedron Letters p. 1813 - 1816 (1997)
Update date:2022-09-26
Topics:
Merino, Pedro
Lanaspa, Ana
Merchan, Francisco L.
Tejero, Tomas
A straightforward synthesis of 2,3-diaminobutanoic acids is reported. The synthesis is based on the nucleophilic addition of methylmagnesium bromide to differentially protected nitrones derived from L-serine. The change of the protecting groups in the starting nitrone is crucial for the stereocontrol of the reaction.
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