Synthesis of 3'-amino and 5'-amino hydantoin 2'-deoxynucleosides

Article abstract of DOI:10.1080/15257779408013274

3'-Amino and 5'-amino derivatives of hydantoin 2'-deoxynucleosides have been prepared from the corresponding 3'-phthalimido and 5'-azido nucleosides, respectively, which in turn were prepared by condensation of appropriate sugars with 5-benzylidenehydantoin. The amino nucleosides were tested for their potential activity against HIV and HSV.

Full text of DOI:10.1080/15257779408013274

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Nucleosides and Nucleotides
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Synthesis of 3′-Amino and 5′-Amino
Hydantoin 2′-Deoxynucleosides
Ahmed A. El-Barbary a c , Ahmed I. Khodair a c , Erik B. Pedersen a &
Claus Nielsen b
a Department of Chemistry , Odense University , DK-5230, Odense M,
Denmark
b Retrovirus Laboratory, Department of Virology , Statens
Seruminstitut, Artillerivej 5, DK-2300, Copenhagen, Denmark
c Chemistry Department, Faculties of Science and Education , Tanta
University , Tanta, Egypt
Published online: 23 Sep 2006.
To cite this article: Ahmed A. El-Barbary , Ahmed I. Khodair , Erik B. Pedersen & Claus Nielsen (1994)
Synthesis of 3′-Amino and 5′-Amino Hydantoin 2′-Deoxynucleosides, Nucleosides and Nucleotides,
13:1-3, 707-717, DOI: 10.1080/15257779408013274
To link to this article: http://dx.doi.org/10.1080/15257779408013274
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