Facile synthesis of (R,S)-(Z) and (R,S)-(E)-N-methyl-(10,11-dihydro-10- hydroxy-5H-dibenzo[a,d]cycloheptene)-Δ(5,γ)-propylamine the major metabolites of amitriptyline and nortriptyline

Article abstract of DOI:10.1080/00397919408010157

Efficient methods for the syntheses of amines 6b and 9b, the major metabolites of the antidepressant drugs amitriptyline 1a and nortriptyline 1b, are described.

Full text of DOI:10.1080/00397919408010157

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Synthetic Communications: An
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Facile Synthesis of (R,S)-
(Z) and (R,S)-(E)-N-Methyl-
(10,11-dihydro-10-hydroxy-5H-
Dibenzo[a,d]cycloheptene)-Δ8,γ-
propylamine. The Major
Metabolites of Amitriptyline
and Nortriptyline
Bertrand J. Jean-Claude a & George Just a
a Department of Chemistry , McGill University
Montréal , Québec, Canada , H3A2K6
Published online: 23 Sep 2006.
To cite this article: Bertrand J. Jean-Claude & George Just (1994) Facile
Synthesis of (R,S)-(Z) and (R,S)-(E)-N-Methyl-(10,11-dihydro-10-hydroxy-5H-
Dibenzo[a,d]cycloheptene)-Δ8,γ-propylamine. The Major Metabolites of Amitriptyline
and Nortriptyline, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 24:11, 1565-1573, DOI:
10.1080/00397919408010157
To link to this article: http://dx.doi.org/10.1080/00397919408010157
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