Studies towards the total synthesis of rapamycin: A convergent and stereoselective synthesis of the C22-C32 carbon framework

DOI: 10.1016/S0040-4039(00)73057-7

Source and publish data:

Tetrahedron Letters p. 2087 - 2090 (1994)

Update date:2022-09-26

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Authors:

Anderson, James C.

Ley, Steven V.

Marsden, Stephen P.

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Article abstract of DOI:10.1016/S0040-4039(00)73057-7

A convergent synthesis of the C₂₂ - C₃₂ portion of rapamycin has been achieved by way of a Nozaki-Kishi coupling of vinyl iodide 14 with aldehyde 13. This aldehyde is available by the stereoselective addition of organometallic reagen

Full text of DOI:10.1016/S0040-4039(00)73057-7

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