Stereoselective synthesis and thromboxane A2 (TXA2) receptor antagonistic activity of optically active phenol derivatives

DOI: 10.1248/cpb.44.749

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 749 - 755 (1996)

Update date:2022-09-26

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Authors:

Fukumoto, Shoji

Terashita, Zen-Ichi

Ashida, Yasuko

Terao, Shinji

Shiraishi, Mitsuru

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Article abstract of DOI:10.1248/cpb.44.749

Enantiomers of four potent nonprostanoid thromboxane A₂ (TXA₂) receptor antagonists, (±)-7-(4-fluorophenyl)-7-(2-hydroxyphenyl)heptanoic acids (1- 4), were synthesized stereoselectively by direct ortho-alkylation of phenols under mod

Full text of DOI:10.1248/cpb.44.749

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Product name:(R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

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