Stereoselective synthesis and thromboxane A2 (TXA2) receptor antagonistic activity of optically active phenol derivatives

DOI: 10.1248/cpb.44.749

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 749 - 755 (1996)

Update date:2022-09-26

Topics:

Authors:

Fukumoto, Shoji

Terashita, Zen-Ichi

Ashida, Yasuko

Terao, Shinji

Shiraishi, Mitsuru

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.44.749

Enantiomers of four potent nonprostanoid thromboxane A₂ (TXA₂) receptor antagonists, (±)-7-(4-fluorophenyl)-7-(2-hydroxyphenyl)heptanoic acids (1- 4), were synthesized stereoselectively by direct ortho-alkylation of phenols under mod

Full text of DOI:10.1248/cpb.44.749

NII-Electronic Library Service

Products guided by the article

Product name:(R)-7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-indan-5-yl)-heptanoic acid methyl ester

Cas No:156558-05-3

R&D Labs maybe for 156558-05-3

Nanjing Maycrop Chemical Co.,Ltd

Contact:86-15345189349

Address:BUILDING 3,DEYING INTERNATIONAL PLAZA,NO.222 CHANGHONG ROAD,YUHUATAI,NANJING,CHINA
Jiangsu Cale New Material Co.ltd

Contact:+86-515-88334667/88203550

Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
Jintan Jinnuo Chemical Co., Ltd.

Contact:+86-519-80199901

Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Ningbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.

Contact:+86-(574)-81110986

Address:No. 1210, Building 3, Wante Business Centre, Hi-tech Zone, Ningbo
ZHIJIANG ZENVA SINO COMMERCE AND TRADE CO., LTD.

website:http://www.zenvasino.com

Contact:+86-138-72658998

Address:Shibeishan Road,Zhijiang, Hubei, China

Relevant to this article

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M₄ PAMs

Doi:10.1016/j.bmcl.2019.06.032
(2019)
Antimycobacterial activity of nitrogen heterocycles derivatives: Bipyridine derivatives. Part III [13,14]

Doi:10.1016/j.ejmech.2013.09.061
(2014)
Synthesis and evaluation of antiproliferative activity of a novel series of hydroxychavicol analogs

Doi:10.1016/j.ejmech.2014.01.016
(2014)
A stereocontrolled route to 2-substituted chromans

Doi:10.1016/S0040-4039(00)01530-6
(2000)
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

Doi:10.1021/acs.jmedchem.9b01760
(2020)
Phenothiazine-bridged cyclic porphyrin dimers as high-affinity hosts for fullerenes and linear array of C₆₀ in self-assembled porphyrin nanotube

Doi:10.1021/jo500034f
(2014)

Article Doi