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Journal of Medicinal Chemistry
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Enzymatic activity of PEDV Mpro, structural
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virus:
Song, D.; Park, B. Porcine epidemic diarrhoea
comprehensive review of molecular
overview and comparison of PEDV Mproꢀ
compound 1 interaction, inhibition kinetics of
compounds 3 and 15, Xꢀray data collection and
refinement statistics, details and characterization
data including purity for all 17 compounds,
additional methods (PDF)
a
epidemiology, diagnosis, and vaccines. Virus Genes
2012, 44, 167ꢀ175.
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particles associated with porcine epidemic diarrhoea.
Res. Vet. Sci. 1978, 25, 255ꢀ256.
Chasey, D.; Cartwright, S. F. Virusꢀlike
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PDB coordinates for complex structure of PEDV
4.
Wood, E. N. An apparently new syndrome of
Mpro with compound 1 (PDB)
porcine epidemic diarrhoea. Vet. Rec. 1977, 100, 243ꢀ
244.
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Molecular formula strings and some data (CSV)
Li, W.; Li, H.; Liu, Y.; Pan, Y.; Deng, F.; Song,
Accession Codes
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Atomic coordinates for the crystal structure of PEDV
Mpro in complex with compound 1 can be accessed
using PDB ID 5GWZ. Authors will release the atomic
coordinates and experimental data upon article
publication.
Y.; Tang, X.; He, Q. New variants of porcine epidemic
diarrhea virus, China, 2011. Emerging Infect. Dis.
2012, 18, 1350ꢀ1353.
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Sun, R. Q.; Cai, R. J.; Chen, Y. Q.; Liang, P.
S.; Chen, D. K.; Song, C. X. Outbreak of porcine
epidemic diarrhea in suckling piglets, China. Emerging
Infect. Dis. 2012, 18, 161ꢀ163.
AUTHOR INFORMATION
Corresponding Authors
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Stevenson, G. W.; Hoang, H.; Schwartz, K. J.;
*H.Y.: phone, +86 22 27403906; fax, +86 22
27403902; eꢀmail, yanght@tju.edu.cn.
*C.Y.: phone, +86 22 65378009; fax, +86 22
65378036; eꢀmail, caiyan_86@163.com.
Author Contributions
Burrough, E. R.; Sun, D.; Madson, D.; Cooper, V. L.;
Pillatzki, A.; Gauger, P.; Schmitt, B. J.; Koster, L. G.;
Killian, M. L.; Yoon, K. J. Emergence of porcine
epidemic diarrhea virus in the United States: clinical
signs, lesions, and viral genomic sequences. J. Vet.
Diagn. Invest. 2013, 25, 649ꢀ654.
+F.W., C.C., and K.Y. contributed equally and are
considered as coꢀfirst authors. All authors have given
approval to the final version of this manuscript.
Notes
8.
Marthaler, D.; Bruner, L.; Collins, J.; Rossow,
K. Third strain of porcine epidemic diarrhea virus,
United States. Emerging Infect. Dis. 2014, 20, 2162ꢀ
2163.
The authors declare no competing financial interest.
9.
Schulz, L. L.; Tonsor, G. T. Assessment of the
economic impacts of porcine epidemic diarrhea virus
in the United States. J. Anim. Sci. 2015, 93, 5111ꢀ5118.
ACKNOWLEDGEMENTS
We thank Dunquan Jiang for data collection at
beamline BLꢀ5A (the Photon Factory, KEK, Japan)
and Steve C. Ding for helpful discussion. This work
was supported by the National Key Basic Research
10.
Kweon, C. H.; Kwon, B. J.; Lee, J. G.; Kwon,
G. O.; Kang, Y. B. Derivation of attenuated porcine
epidemic diarrhea virus (PEDV) as vaccine candidate.
Vaccine 1999, 17, 2546ꢀ2553.
Program
of
China
(973
program,
grant
2015CB859800), the Binhai New Area Special Fund
for Innovations in Science and Technology, the
National Natural Science Foundation of China (grant
31528006), the National Key Research Program of
China (No. 2016YFD0500300), and the Tianjin Marine
Science and Technology Program (grant KJXH2014ꢀ
16).
11.
Song, D. S.; Oh, J. S.; Kang, B. K.; Yang, J. S.;
Moon, H. J.; Yoo, H. S.; Jang, Y. S.; Park, B. K. Oral
efficacy of Vero cell attenuated porcine epidemic
diarrhea virus DR13 strain. Res. Vet. Sci. 2007, 82,
134ꢀ140.
12.
Kim, S. H.; Lee, J. M.; Jung, J.; Kim, I. J.;
Hyun, B. H.; Kim, H. I.; Park, C. K.; Oem, J. K.; Kim,
Y. H.; Lee, M. H.; Lee, K. K. Genetic characterization
of porcine epidemic diarrhea virus in Korea from 1998
to 2013. Arch. Virol. 2015, 160, 1055ꢀ1064.
ABBREVIATIONS USED
PED, porcine epidemic diarrhea; PEDV, Porcine
Epidemic Diarrhea Virus; Mpro, main protease; SARS,
severe acute respiratory syndrome; MERS, Middle
East respiratory syndrome.
13.
Lee, D. K.; Park, C. K.; Kim, S. H.; Lee, C.
Heterogeneity in spike protein genes of porcine
epidemic diarrhea viruses isolated in Korea. Virus Res.
2010, 149, 175ꢀ182.
14.
Brian, D. A.; Baric, R. S. Coronavirus genome
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