Synthesis p. 1261 - 1266 (1993)
Update date:2022-08-05
Topics:
Robles
Pedroso
Grandas
A new base-labile carboxyl protecting group, the 2-(4-acetyl-2-nitrophenyl)ethyl (Anpe) group is reported and compared with other base-labile protecting groups. The synthesis of the alcohol precursor, 1-[4-(2-hydroxyethyl)-3-nitrophenyl]-1-ethanone, the amino acid derivatives Boc-Asp(Anpe)-OH and Boc-Glu(Anpe)-OH and the conditions under which the carboxyl protecting group can be eliminated are also described.
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Doi:10.1016/j.tetlet.2014.01.071
(2014)Doi:10.1007/BF01431116
(1996)Doi:10.1039/c3cc49526d
(2014)Doi:10.1016/0022-328X(94)88135-9
(1994)Doi:10.1002/adsc.201300559
(2013)Doi:10.1016/j.tetlet.2014.01.079
(2014)