Classical and Nonclassical Furopyrimidines as Novel Antifolates: Synthesis and Biological Activities

DOI: 10.1021/jm00034a015

Source and publish data:

Journal of Medicinal Chemistry p. 1169 - 1176 (1994)

Update date:2022-08-03

Topics:

Authors:

Gangjee, Aleem

Devraj, Rajesh

McGuire, John J.

Kisliuk, Roy L.

Queener, Sherry F.

Barrows, Louis R.

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Article abstract of DOI:10.1021/jm00034a015

Classical antifolate analogues containing a novel furo<2,3-d>pyrimidine ring system which include N-<4-N-<(2,4-diaminofuro<2,3-d>pyrimidin-5-yl)methyl>amino>benzoyl>-L-glutamic acid (1) and its N-9 methyl analogue 2 were synthesized as potential dual inhi

Full text of DOI:10.1021/jm00034a015

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