Classical and Nonclassical Furopyrimidines as Novel Antifolates: Synthesis and Biological Activities

DOI: 10.1021/jm00034a015

Source and publish data:

Journal of Medicinal Chemistry p. 1169 - 1176 (1994)

Update date:2022-08-03

Topics:

Authors:

Gangjee, Aleem

Devraj, Rajesh

McGuire, John J.

Kisliuk, Roy L.

Queener, Sherry F.

Barrows, Louis R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00034a015

Classical antifolate analogues containing a novel furo<2,3-d>pyrimidine ring system which include N-<4-N-<(2,4-diaminofuro<2,3-d>pyrimidin-5-yl)methyl>amino>benzoyl>-L-glutamic acid (1) and its N-9 methyl analogue 2 were synthesized as potential dual inhi

Full text of DOI:10.1021/jm00034a015

Products guided by the article

Product name:N-(4-(N-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid

Cas No:156595-84-5

R&D Labs maybe for 156595-84-5

Jiaxing Anrui Material Technology Co., Ltd.

Contact:86-573-82651652 13305832579

Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
Nanjing Zelang Medical Technology Co. Ltd

Contact:86-25-83063290/13770714480

Address:Ganjiabian 108# 01 Unit,701-702 room,Yao Hua Street,Qixia District,Nanjing,Jiangsu,China
Anhui Qingyun Pharmaceutical and Chemical Co.,Ltd

Contact:+86-551-63633067

Address:Shuangfeng Road Hefei Anhui
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Shanghai Massive Chemical Technology Co., Ltd.

website:http://www.massivechem.com/

Contact:+86 21 34943721

Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,

Relevant to this article

Ultrasound-promoted synthesis of substituted phenanthrene-1,4-quinones; the structure of plectranthon D

Doi:10.1016/S0040-4039(00)76783-9
(1994)
Synthesis of β-hydroxy-γ-trimethylsilyl-γ-butyrolactone as key chiral building block for preparation of four-carbon chain units having tertiary stereogenic carbon

Doi:10.1016/S0040-4039(00)73364-8
(1994)
Nine-vertex Polyhedral Iridamonocarbaborane Chemistry. Products of Thermolysis of <(CO)(PPh3)2IrCB7H8> and Emerging Alternative Cluster-geometry Patterns

Doi:10.1039/DT9940000229
(1994)
The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships

Doi:10.1016/j.bmcl.2014.01.021
(2014)
Asymmetric syntheses of nakinadine D, nakinadine E, and nakinadine F: Confirmation of their relative (RS, SR)-configurations and proposal of their absolute (2 S,3 R)-configurations

Doi:10.1021/acs.joc.5b00376
(2015)
Halogen effects on photoluminescence and catalytic properties: A series of spatially arranged trimetallic zinc(ii) complexes

Doi:10.1039/c3dt53137f
(2014)

Article Doi