Classical and Nonclassical Furopyrimidines as Novel Antifolates: Synthesis and Biological Activities

DOI: 10.1021/jm00034a015

Source and publish data:

Journal of Medicinal Chemistry p. 1169 - 1176 (1994)

Update date:2022-08-03

Topics:

Authors:

Gangjee, Aleem

Devraj, Rajesh

McGuire, John J.

Kisliuk, Roy L.

Queener, Sherry F.

Barrows, Louis R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00034a015

Classical antifolate analogues containing a novel furo<2,3-d>pyrimidine ring system which include N-<4-N-<(2,4-diaminofuro<2,3-d>pyrimidin-5-yl)methyl>amino>benzoyl>-L-glutamic acid (1) and its N-9 methyl analogue 2 were synthesized as potential dual inhi

Full text of DOI:10.1021/jm00034a015

Products guided by the article

Product name:N-(4-(N-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid

Cas No:156595-84-5

R&D Labs maybe for 156595-84-5

Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Beyond Pharmaceutical Co., Ltd

Contact:+86-571-8195-3185

Address:No. 13-1, Liansheng Road, Yuhang District
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)

Contact:051989185693

Address:NO 217 huangshan Rd ,Changzhou
Synochem Ingredients Corp., Ltd.

Contact:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone
Tangshan Moneide Trading Co., Ltd.

Contact:+86-315-8309571

Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China

Relevant to this article

Ultrasound-promoted synthesis of substituted phenanthrene-1,4-quinones; the structure of plectranthon D

Doi:10.1016/S0040-4039(00)76783-9
(1994)
Synthesis of β-hydroxy-γ-trimethylsilyl-γ-butyrolactone as key chiral building block for preparation of four-carbon chain units having tertiary stereogenic carbon

Doi:10.1016/S0040-4039(00)73364-8
(1994)
Nine-vertex Polyhedral Iridamonocarbaborane Chemistry. Products of Thermolysis of <(CO)(PPh3)2IrCB7H8> and Emerging Alternative Cluster-geometry Patterns

Doi:10.1039/DT9940000229
(1994)
The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships

Doi:10.1016/j.bmcl.2014.01.021
(2014)
Asymmetric syntheses of nakinadine D, nakinadine E, and nakinadine F: Confirmation of their relative (RS, SR)-configurations and proposal of their absolute (2 S,3 R)-configurations

Doi:10.1021/acs.joc.5b00376
(2015)
Halogen effects on photoluminescence and catalytic properties: A series of spatially arranged trimetallic zinc(ii) complexes

Doi:10.1039/c3dt53137f
(2014)

Article Doi