Synthesis of β-hydroxy-γ-trimethylsilyl-γ-butyrolactone as key chiral building block for preparation of four-carbon chain units having tertiary stereogenic carbon

Article abstract of DOI:10.1016/S0040-4039(00)73364-8

A new chiral building block β-hydroxy-γ-trimethylsilyl-γ-butyrolactone (1) was prepared from γ-trimethylsilylallyl acetate (2) via two steps in excellent overall yield. The lactone 1 is a useful precursor to four-carbon chain blocks having tertiary stereogenic centers such as 6, 10 and 11.