Synthesis of a Photoactivatable 9-Z-Oleic Acid For Protein Kinase C Labeling

Article abstract of DOI:10.1016/S0040-4020(01)90398-9

A convenient synthesis of (Z)-18-<4-<3(trifluoromethyl)diazirinyl>phenyl>-9-octadecenoic acid (13) for photoaffinity labeling is described.Photochemical experiments on 13 and its precursor 11 in ethanol solution as well as in an argon matrix at 12 K demonstrate the formation of diazo compounds and ultimately carbene-derived products.