Na+-glucose cotransporter inhibitors as antidiabetic agents. II. Synthesis and structure-activity relationships of 4'-dehydroxyphlorizin derivatives

DOI: 10.1248/cpb.46.22

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 22 - 33 (1998)

Update date:2022-08-05

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Authors:

Hongu, Mitsuya

Tanaka, Takashi

Funami, Nobuyuki

Saito, Kunio

Arakawa, Kenji

Matsumoto, Mamoru

Tsujihara, Kenji

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Article abstract of DOI:10.1248/cpb.46.22

A novel series of 4'-dehydroxyphlorizin derivatives was synthesized and the effects of these compounds on urinary glucose excretion were evaluated in rats. There was a strict structural requirement for activity. Introduction of a small substituent or a fi

Full text of DOI:10.1248/cpb.46.22

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