2,5-Disubstituted Pyrrolidines from D-Mannitol-Derived Bis-Aziridines

DOI: 10.1016/0040-4039(94)88023-9

Source and publish data:

Tetrahedron Letters p. 1201 - 1204 (1994)

Update date:2022-07-30

Topics:

Authors:

Fitremann,Juliette

Dureault, Annie

Depezay, Jean-Claude

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Article abstract of DOI:10.1016/0040-4039(94)88023-9

Concise synthesesof 3,4-dihydroxy-2,5-disubstituted pyrrolidines have been achieved starting from D-mannitol-derived flexible L-Ido bis-aziridines.Nucleophilic ring opening of the N-Boc and N-Cbz activated bis-aziridines by phenylthiolate and azide ions h

Full text of DOI:10.1016/0040-4039(94)88023-9

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