Synthesis and pharmacological evaluation of verapamil analogs with restricted molecular flexibility

DOI: 10.1016/0223-5234(94)90211-9

Source and publish data:

European Journal of Medicinal Chemistry p. 139 - 148 (1994)

Update date:2022-08-05

Topics:

Authors:

Teodori, E.

Dei, S. Dei, S.

Romanelli, M. N.

Scapecchi, S.

Gualtieri, F.

et al. et al.

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Article abstract of DOI:10.1016/0223-5234(94)90211-9

Several analogs of verapamil, which are characterized by a reduced molecular flexibility, have been synthesized.Their pharmacological activity has been evaluated on guinea-pig atria (negative chronotropic and inotropic activities) and guinea-pig aorta str

Full text of DOI:10.1016/0223-5234(94)90211-9

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