Gold(I)-catalyzed asymmetric aldol reactions of fluorinated benzaldehydes with an α-isocyanoacetamide

Article abstract of DOI:10.1016/0957-4166(94)80059-6

The use of N,N-dimethyl-α-isocyanoacetamide instead of methyl α-isocyanoacetate in the gold(I)-catalyzed asymmetric aldol reactions with polyfluorinated benzaldehydes was found to improve both diastereo- and enantioselectivity in the formation of trans-ox