Synthesis of combretastatin D-2. An efficient route to caffrane macrolactones

DOI: 10.1016/S0040-4039(00)73369-7

Source and publish data:

Tetrahedron Letters p. 4409 - 4412 (1994)

Update date:2022-07-31

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Authors:

Couladouros, Elias A.

Soufli, Ioanna C.

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Article abstract of DOI:10.1016/S0040-4039(00)73369-7

Combretastatin D-2, (1), was synthesized via a 10 step sequence. Macrolactonization was performed saturated substrate 12 in high yield and the double bond was established via dehalogenation of intermediate 15.

Full text of DOI:10.1016/S0040-4039(00)73369-7

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