Synthesis, Resolution, and SAR of (+/-)-2-Amino-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine and Related Analogs as Noncompetitive NMDA Antagonists with Neuroprotective Properties

DOI: 10.1021/jm00045a004

Source and publish data:

Journal of Medicinal Chemistry p. 3008 - 3015 (1994)

Update date:2022-08-05

Topics: Synthesis Resolution SAR (Structure-Activity Relationship)

Authors:

Martin, Lawrence L.

Lee, George E.

Lee, Thomas B. K.

Rush, Douglas K.

Wilmot, Carole A.

et al. et al.

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Article abstract of DOI:10.1021/jm00045a004

The preparation and structure-activity relationships of a series of 2-amino-α-thienylbenzeneethanamines are described.From this work, (+/-)-2-amino-N-methyl-α-(3-methyl-2-thienyl)-benzeneethanamine (3a) and the homologous N-ethyl analog 3b emerged as nove

Full text of DOI:10.1021/jm00045a004

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