A β,β,β-Trialkoxyethyllithium Stable towards Fragmentation: a Carboxyl Protected Acetic Acid Dianion Equivalent

Article abstract of DOI:10.1016/S0040-4020(01)85292-3

The novel alkyllithium 1b is not only intriguinly stable towards fragmentation, but also a synthetically useful reagent, complementing current carboxylic ester enolate methodology.Its design is based on interesting mechanistic principles, and harnesses the known stability of the 2,4,10-trioxaadamantane framework.