The synthesis of β-heteroarylamino-α,β-dehydro-α-amino acid derivatives via thiazolones

Article abstract of DOI:10.1002/jhet.5570310133

2-Alkoxy-4-heteroarylaminomethylene-5(4H)-thiazolones 4 were converted with various nucleophiles into β-heteroarylamino-α,β-dehydro-α-amino acid derivatives 11, 14, 15, 16, 17, 18, and 19. Reduction of 4 with sodium borohydride in ethanol saturated with g