A New Method for the Synthesis of Nε-Acetyl-Nε-hydroxy-L-lysine, the Iron-Binding Constituent of Several Important Siderophores

Article abstract of DOI:10.1021/jo00096a030

Oxidation of the ε-amino group of N^α-(carbobenzyloxy)-L-lysine methyl ester with dimethyldioxirane in acetone gave the acetone-derived nitrone of the desired hydroxylamine.Acidic hydrolysis, acetylation, and subsequent deprotection provided a s