2-Monosubstituted-1,3-Oxazolidines as Improved Protective Groups of N-Boc-Phenylisoserine in Docetaxel Preparation

DOI: 10.1016/0040-4039(94)85217-0

Source and publish data:

Tetrahedron Letters p. 2349 - 2352 (1994)

Update date:2022-08-03

Topics:

Authors:

Didier, Eric

Foque, Elie

Taillepied, Isabelle

Commercon, Alain

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Article abstract of DOI:10.1016/0040-4039(94)85217-0

A new route for semisynthetic docetaxel, 1, is desribed using 2-monosubstituted-4-phenyl-1,3-oxazolidine-5-carboxylic acids in esterification of 7,10-O-diTroc-10-desacetylbaccatin III (4).Subsequent deprotection of esters 10(+10') afforded title compound 1 without removal of the Boc group.

Full text of DOI:10.1016/0040-4039(94)85217-0

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