Some reactions of 16α,17α-oxido-5α-cholestane derivatives, synthesis of 17α-hydroxycholest-4-en-3-one

Article abstract of DOI:10.1016/0039-128X(94)90123-6

Careful epoxidation of the Δ¹⁶-olefins 3 and 4 yielded 16α,17α- epoxides 5 and 6 which were reduced by lithium aluminium hydride, oxidized, and dehydrated to 17α-hydroxycholest-4-en-3-one 20, i.e., an epitestosterone homolog containing a well t