Journal of Antibiotics p. 357 - 369 (1994)
Update date:2022-07-31
Topics:
Nishi
Higashi
Soga
Takemura
Sato
A series of new penems (4 ~ 17), having a bicyclic imidazole moiety as the C-2 substituent, has been synthesized. The antimicrobial activity of these compounds and their susceptibility to renal dehydropeptidase-1 (DHP-1) are elucidated, and their structure-activity relationships are discussed.
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