Diastereoselective bis-alkylation of chiral non-racemic α,β-unsaturated γ-lactams

DOI: 10.1016/S0040-4039(00)76705-0

Source and publish data:

Tetrahedron Letters p. 3931 - 3934 (1994)

Update date:2022-07-30

Topics:

Authors:

Baussanne, Isabelle

Chiaroni, Angele

Husson, Henri-Philippe

Riche, Claude

Royer, Jacques

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Article abstract of DOI:10.1016/S0040-4039(00)76705-0

A new chiral non-racemic γ-lactam 1 easily prepared in one step from (R)-(-)-phenylglycinol was bis-alkylated α to the carbonyl function in very high to complete diastereoselectivity. The stereochemistry at the so-formed chiral quaternary center was ascertained through an X-ray crystallographic study.

Full text of DOI:10.1016/S0040-4039(00)76705-0

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