Diastereoselective bis-alkylation of chiral non-racemic α,β-unsaturated γ-lactams

DOI: 10.1016/S0040-4039(00)76705-0

Source and publish data:

Tetrahedron Letters p. 3931 - 3934 (1994)

Update date:2022-07-30

Topics:

Authors:

Baussanne, Isabelle

Chiaroni, Angele

Husson, Henri-Philippe

Riche, Claude

Royer, Jacques

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)76705-0

A new chiral non-racemic γ-lactam 1 easily prepared in one step from (R)-(-)-phenylglycinol was bis-alkylated α to the carbonyl function in very high to complete diastereoselectivity. The stereochemistry at the so-formed chiral quaternary center was ascertained through an X-ray crystallographic study.

Full text of DOI:10.1016/S0040-4039(00)76705-0

Products guided by the article

Product name:3-Benzyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one

Cas No:158271-98-8

R&D Labs maybe for 158271-98-8

Hangzhou LINGEBA Technology Co., Ltd.

Contact:+0086-571-87389059

Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
YORK CHEMICALS LTD

Contact:+1 (647) 918 5848

Address:2343 BRIMLEY RD., Suite 250
Shenyang Mole pharmaceutical Technology Development Co.,Ltd

Contact:+86-24-31204918/13889278616

Address:No.44, wanliutang road, shenhe District of Shenyang
Zhejiang Tianyu Pharmaceutical Co., Ltd.

Contact:+86-576-84177669, 89189665,89189688,84168770

Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
Cangzhou Senary Chemical Science-tech Co., Ltd

Contact:+86-317-3563899, 3563699

Address:168 Jinde Road, Cangzhou, Hebei, China

Relevant to this article

Studies into the preparation of 1-deoxy-1-thiocyanato-D-glycopyranosyl cyanides and the anomeric effect of the thiocyanate group

Doi:10.1016/S0957-4166(01)00112-4
(2001)
Discovery of anilinopyrimidines as dual inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and cellular activity

Doi:10.1021/ml500066m
(2014)
A Corey–Seebach Macrocyclisation Strategy for the Synthesis of Riccardin C and an Unnatural Macrocyclic Bis(bibenzyl) Analogue

Doi:10.1002/ejoc.201601179
(2016)
AN ISOFLAVONE GLYCOSIDE FROM THE SEEDS OF TRICHOSANTHES ANGUINA

Doi:10.1016/S0031-9422(00)89754-X
(1994)
Fluorometric sensing of Hg²⁺ ions in aqueous medium by nano-aggregates of a tripodal receptor

Doi:10.1039/c3ob42200c
(2014)
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Doi:10.1016/j.bmcl.2005.09.051
(2006)

Article Doi