Diastereoselective bis-alkylation of chiral non-racemic α,β-unsaturated γ-lactams

DOI: 10.1016/S0040-4039(00)76705-0

Source and publish data:

Tetrahedron Letters p. 3931 - 3934 (1994)

Update date:2022-07-30

Topics:

Authors:

Baussanne, Isabelle

Chiaroni, Angele

Husson, Henri-Philippe

Riche, Claude

Royer, Jacques

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)76705-0

A new chiral non-racemic γ-lactam 1 easily prepared in one step from (R)-(-)-phenylglycinol was bis-alkylated α to the carbonyl function in very high to complete diastereoselectivity. The stereochemistry at the so-formed chiral quaternary center was ascertained through an X-ray crystallographic study.

Full text of DOI:10.1016/S0040-4039(00)76705-0

Products guided by the article

Product name:3-Benzyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,5-dihydro-pyrrol-2-one

Cas No:158271-98-8

R&D Labs maybe for 158271-98-8

Jinan Trio PharmaTech Co., Ltd

Contact:86-531-88811783；+(0)13153010282

Address:2766 Yingxiu Road, Jinan High-Tech Zone, China
Allicon Pharmaceuticals,Inc.

Contact:+86-519-86339586，13584329896

Address:Changzhou Scientific and Education Park
Zouping Fuhai Technology Development Co., Ltd.

Contact:+0532-86934525 18660293207

Address:jiuhu town industrial park Zouping County,bingzhou Provincejiuhu town industrial park
Changzhou BaoKang Pharmaceutical & Chemical Co., Ltd

Contact:(86) 519-88782201 88784080 88785278

Address:Henglin town, changzhou,Jiangsu
KangZhiYuan Pharmaceutical Company Limited

Contact:(Sabrina)86-20-85273232

Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China

Relevant to this article

Studies into the preparation of 1-deoxy-1-thiocyanato-D-glycopyranosyl cyanides and the anomeric effect of the thiocyanate group

Doi:10.1016/S0957-4166(01)00112-4
(2001)
Discovery of anilinopyrimidines as dual inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and cellular activity

Doi:10.1021/ml500066m
(2014)
A Corey–Seebach Macrocyclisation Strategy for the Synthesis of Riccardin C and an Unnatural Macrocyclic Bis(bibenzyl) Analogue

Doi:10.1002/ejoc.201601179
(2016)
AN ISOFLAVONE GLYCOSIDE FROM THE SEEDS OF TRICHOSANTHES ANGUINA

Doi:10.1016/S0031-9422(00)89754-X
(1994)
Fluorometric sensing of Hg²⁺ ions in aqueous medium by nano-aggregates of a tripodal receptor

Doi:10.1039/c3ob42200c
(2014)
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Doi:10.1016/j.bmcl.2005.09.051
(2006)

Article Doi