Stereoselective bromination of β-ribofuranosyl amide. Enantioselective synthesis of (+)-hydantocidin

Article abstract of DOI:10.1016/S0040-4039(00)77049-3

The synthesis of hydantocidin, a potent herbicidal natural product, is highlighted by a stereoselective bromination of β-D-ribofuranosyl amide to give only the α-bromo β-amide and subsequent spirocyclization about the anomeric position with silver cyanate to form the hydantoin moiety.