Tetrahedron Letters p. 6017 - 6020 (1994)
Update date:2022-08-05
Topics:
Ku, Yi-Yin
Patel, Ramesh R.
Roden, Brian A.
Sawick, David P.
A simple method for the introduction of the N-hydroxyurea functionality has been developed.This involves conjugate addition of hydroxylamine to a vinylsulfone substrate.This method was successfully used in a facile synthesis of the 5-lipoxygenase inhibitors, zileuton and A-69412.
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