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Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection

DOI: 10.1016/j.jconrel.2018.10.010

Source and publish data:

Journal of Controlled Release p. 102 - 111 (2018)

Update date:2022-07-29

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Authors:

Pashirova, Tatiana N.Pashirova, Tatiana N.

Bra?ki, AnissaBra?ki, Anissa

Zueva, Irina V.Zueva, Irina V.

Petrov, Konstantin A.Petrov, Konstantin A.

Babaev, Vasily M.Babaev, Vasily M.

Burilova, Evgenia A.Burilova, Evgenia A.

Samarkina, Darya A.Samarkina, Darya A.

Rizvanov, Ildar Kh.Rizvanov, Ildar Kh.

Souto, Eliana B.Souto, Eliana B.

Jean, LudovicJean, Ludovic

Renard, Pierre-YvesRenard, Pierre-Yves

Masson, PatrickMasson, Patrick

Zakharova, Lucia Ya.Zakharova, Lucia Ya.

Sinyashin, Oleg G.Sinyashin, Oleg G.

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Article abstract of DOI:10.1016/j.jconrel.2018.10.010

A novel approach for brain protection against poisoning by organophosphorus agents is developed based on the combination treatment of dual delivery of two oximes. Pralidoxime chloride (2-PAM) and a novel reactivator, 6-(5-(6,7-dimethoxy-3,4-dihydroisoquin

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Full text of DOI:10.1016/j.jconrel.2018.10.010

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Product name:methyl 3-(benzyloxy)-6-(5-hydroxypent-1-ynyl)picolinate

Cas No:1585949-24-1

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