Synthesis and anti-HIV activity of 5-fluorocytallene: N- dimethylaminomethylene as a facilitating group in acetylene → allene isomerization

Article abstract of DOI:10.1080/15257779408009480

The synthesis and biological activity of 5-fluorocytallene (3a) is described. 5-Fluorocytosine (4) was alkylated with 1-benzoyloxy-4-bromo-2- butyne (5) to give N¹-(4-benzoyloxy-2-butyn-1-yl)-5-fluorocytosine (6). Debenzoylation led to N^1<

Full text of DOI:10.1080/15257779408009480

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Synthesis and Anti-HIV Activity
of 5-Fluorocytallene: N-
Dimethylaminomethylene as a
Facilitating Group in Acetylene → Allene
Isomerization
C. Simons a , S. Chokekijchai c , H. Mitsuya c & J. Zemlicka a b
a Department of Chemistry , Michigan Cancer Foundation , Detroit,
Michigan, 48201
b Departments of Internal Medicine and Biochemistry , Wayne State
University School of Medicine , Detroit, Michigan, 48201
c The Experimental Retrovirology Section, Medicine Branch, National
Cancer Institute , Bethesda, Maryland, 20892
Published online: 24 Sep 2006.
To cite this article: C. Simons , S. Chokekijchai , H. Mitsuya & J. Zemlicka (1994) Synthesis
and Anti-HIV Activity of 5-Fluorocytallene: N-Dimethylaminomethylene as a Facilitating Group
in Acetylene → Allene Isomerization, Nucleosides and Nucleotides, 13:8, 1779-1789, DOI:
10.1080/15257779408009480
To link to this article: http://dx.doi.org/10.1080/15257779408009480
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