Chemical study on hapalosin, a cyclic depsipeptide possessing multidrug resistance reversing activities: Synthesis, structure and biological activity

DOI: 10.1016/0040-4020(96)00951-9

Source and publish data:

Tetrahedron p. 14723 - 14734 (1996)

Update date:2022-08-04

Topics:

Authors:

Okuno, Toshiaki

Ohmori, Ken

Nishiyama, Shigeru

Yamamura, Shosuke

Nakamura, Kensuke

Houk Houk

Okamoto, Kazuya

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4020(96)00951-9

Hapalosin 1 possessing a multidrug resistance reversing activity, has been synthesized from the corresponding hydroxy acids A, C and γ-amino acid B. The stereochemistry of the natural product 1 and N-demethylhapalosin 11 is discussed by means of spectroscopic manner as well as molecular modeling studies. Biological evaluation of 1 and 11 indicated that a cis-amide function is a crucial factor for the MDR reversing activity.

Full text of DOI:10.1016/0040-4020(96)00951-9

Products guided by the article

Product name:4(S)-Benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetic acid

Cas No:158895-85-3

R&D Labs maybe for 158895-85-3

Jiangsu Fengshan Group Co., Ltd.

Contact:86-25-86558671

Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
Taizhou Elitechemie MediPharma Technology Co.,Ltd.

Contact:+86-523-86810021

Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Yangzhou Siyu Chemical Co.,Ltd.

Contact:+86-514-87325867 13358126196

Address:Room 620 Exposition Pavilion，No. 98 Huaihai Road,Guangling District，Yangzhou City, Jiangsu Province
GIHI CHEMICALS CO.,LIMITED

Contact:+86-571-86217390

Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.
Luoyang Aoda chemical Co.,Ltd.

Contact:+86-379-67518785 67516588

Address:MiaoWan industry district,YanShi City,Henan,China

Relevant to this article

Rate constants for the OH reactions with oxygenated organic compounds in aqueous solution

Doi:10.1002/kin.20405
(2009)
Doi:10.1021/jo01369a001
(1954)
Intramolecular ligation of carbonyl oxygen to central zinc in synthetic oligopeptide-linked zinc-porphyrins

Doi:10.1246/bcsj.67.2478
(1994)
Total synthesis of Iejimalide B

Doi:10.1021/jo200514m
(2011)
The synthesis of a corrole analogue of aquacobalamin (Vitamin B _12a) and its ligand substitution reactions

Doi:10.1021/ic5000793
(2014)
Prevention of mitochondrial membrane permeabilization and pancreatic β-cell death by an enantioenriched, macrocyclic small molecule

Doi:10.1002/ejoc.201301769
(2014)

Article Doi