Structure-Activity Relationships of C1 and C6 Side Chains of Zaragozic Acid A Derivatives

DOI: 10.1021/jm00049a022

Source and publish data:

Journal of Medicinal Chemistry p. 4031 - 4051 (1994)

Update date:2022-08-03

Topics:

Authors:

Ponpipom, Mitree M.

Girotra, Narindar N.

Bugianesi, Robert L.

Roberts, Cathleen D.

Berger, Gregory D.

et al. et al.

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Article abstract of DOI:10.1021/jm00049a022

Systematic modification of the C6 acyl side chain of zaragozic acid A, a potent squalene synthase inhibitor, was undertaken to improve its biological activity.Simplification of the C6 side chain to the octanoyl ester has deleterious effects; increasing th

Full text of DOI:10.1021/jm00049a022

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