Structure-Activity Relationships of C1 and C6 Side Chains of Zaragozic Acid A Derivatives

DOI: 10.1021/jm00049a022

Source and publish data:

Journal of Medicinal Chemistry p. 4031 - 4051 (1994)

Update date:2022-08-03

Topics:

Authors:

Ponpipom, Mitree M.

Girotra, Narindar N.

Bugianesi, Robert L.

Roberts, Cathleen D.

Berger, Gregory D.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00049a022

Systematic modification of the C6 acyl side chain of zaragozic acid A, a potent squalene synthase inhibitor, was undertaken to improve its biological activity.Simplification of the C6 side chain to the octanoyl ester has deleterious effects; increasing th

Full text of DOI:10.1021/jm00049a022

Products guided by the article

Product name:(1S,3S,4S,5R,6R,7R)-6-Butyryloxy-4-hydroxy-7-(1-methoxy-1-methyl-ethoxy)-1-((E)-4-phenyl-but-3-enyl)-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid tri-tert-butyl ester

Cas No:158901-99-6

R&D Labs maybe for 158901-99-6

Anhui Sholon New Material Technology Co., Ltd.

website:http://www.sholonchem.com

Contact:+86-550-5261666

Address:4/F Block B, Beijing Chemical Building.No.520 Tianrun Road ,Science & Education Town Wujin District, Changzhou City Jiangsu Province
Zhejiang kehong chemical co., ltd

Contact:0086-575-85522000

Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Wuhan Shengmao Corp

website:http://www.shengmaochem.com

Contact:86-27-82853423, 82819281

Address:Rm 202, A Unit Huaqiao Building No. 2, Lihuangpi Road, Wuhan, China
Taizhou Sunny Chemical Co.,Ltd

Contact:+86-523-86920899 +86-13951172783

Address:No.11 Xingyuang road, Gaoyong Chemical Industry Park, Gaogang Jiangsu China
Shanghai Yuantai Chemical Products Co., Ltd

Contact:021--66129803

Address:Chengyin Road,Shanghai,China

Relevant to this article

Synthesis and Reactions of 3-(Bromomethyl)-1-carbethoxy-4-iodoindole: The Preparation of 3,4-Differentially Substituted Indoles

Doi:10.1021/jo00102a055
(1994)
Synthesis of 1,1-disubstituted tetrahydroisoquinolines by lithiation and substitution, with in situ IR spectroscopy and configurational stability studies

Doi:10.1021/ja500485f
(2014)
Nucleophilic Substitution Reactions of Phenacyl Bromide Oxime: Effect of the Solvent and the Basicity of the Nucleophile

Doi:10.1021/jo00100a062
(1994)
Aromatic nonpolar nucleosides as hydrophobic isosteres of pyrimidine and purine nucleosides

Doi:10.1021/jo00103a013
(1994)
Synthesis of the (α,α-difluoroalkyl)phosphonate analogue of phosphoserine

Doi:10.1016/S0040-4039(00)78242-6
(1994)
Highly efficient four-component synthesis of 4(3H)-quinazolinones: Palladium-catalyzed carbonylative coupling reactions

Doi:10.1002/anie.201308756
(2014)

Article Doi