
Journal of Medicinal Chemistry p. 4031 - 4051 (1994)
Update date:2022-08-03
Topics:
Ponpipom, Mitree M.
Girotra, Narindar N.
Bugianesi, Robert L.
Roberts, Cathleen D.
Berger, Gregory D.
et al.
Systematic modification of the C6 acyl side chain of zaragozic acid A, a potent squalene synthase inhibitor, was undertaken to improve its biological activity.Simplification of the C6 side chain to the octanoyl ester has deleterious effects; increasing th
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