Structure-Activity Relationships of C1 and C6 Side Chains of Zaragozic Acid A Derivatives

DOI: 10.1021/jm00049a022

Source and publish data:

Journal of Medicinal Chemistry p. 4031 - 4051 (1994)

Update date:2022-08-03

Topics:

Authors:

Ponpipom, Mitree M.

Girotra, Narindar N.

Bugianesi, Robert L.

Roberts, Cathleen D.

Berger, Gregory D.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00049a022

Systematic modification of the C6 acyl side chain of zaragozic acid A, a potent squalene synthase inhibitor, was undertaken to improve its biological activity.Simplification of the C6 side chain to the octanoyl ester has deleterious effects; increasing th

Full text of DOI:10.1021/jm00049a022

Products guided by the article

Product name:(1S,3S,4S,5R,6R,7R)-6-Butyryloxy-4-hydroxy-7-(1-methoxy-1-methyl-ethoxy)-1-((E)-4-phenyl-but-3-enyl)-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid tri-tert-butyl ester

Cas No:158901-99-6

R&D Labs maybe for 158901-99-6

chengdu firsterchem Pharmaceutical Co., Ltd.

Contact:028-66825849

Address:chengdu
Shanghai Dano Pharmaceutical Co.,Ld.(expird)

Contact:+86-592-6266840

Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China
ABA Chemicals (Shanghai) Limited

Contact:021- 5115 9199-232

Address:Suite 18D, #201 Ningxia Road,
Tocopharm Co., Ltd.

Contact:+86-021-6989-5597

Address:No.80 Yichuan Rd., Putuo District,Shanghai,P.R.China
Jingzhou TianHe Sci&Tech Chemical Co., Ltd.

Contact:86-716-8331612

Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province

Relevant to this article

Synthesis and Reactions of 3-(Bromomethyl)-1-carbethoxy-4-iodoindole: The Preparation of 3,4-Differentially Substituted Indoles

Doi:10.1021/jo00102a055
(1994)
Synthesis of 1,1-disubstituted tetrahydroisoquinolines by lithiation and substitution, with in situ IR spectroscopy and configurational stability studies

Doi:10.1021/ja500485f
(2014)
Nucleophilic Substitution Reactions of Phenacyl Bromide Oxime: Effect of the Solvent and the Basicity of the Nucleophile

Doi:10.1021/jo00100a062
(1994)
Aromatic nonpolar nucleosides as hydrophobic isosteres of pyrimidine and purine nucleosides

Doi:10.1021/jo00103a013
(1994)
Synthesis of the (α,α-difluoroalkyl)phosphonate analogue of phosphoserine

Doi:10.1016/S0040-4039(00)78242-6
(1994)
Highly efficient four-component synthesis of 4(3H)-quinazolinones: Palladium-catalyzed carbonylative coupling reactions

Doi:10.1002/anie.201308756
(2014)

Article Doi