A NEW PROCEDURE FOR CONSTRUCTION OF 2,6-TRANS-DISUBSTITUTED PIPERIDINES USING OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION: APPLICATION TO THE SYNTHESIS OF (+)-EPIDIHYDROPINIDINE AND (+)-SOLENOPSIN A

Article abstract of DOI:10.3987/COM-94-6803

An asymmetric synthesis of (+)-epidihydropinidine (1) and (+)-solenopsin A (2) has been achieved by starting with the Sharpless asymmetric dihydroxylation of the α-amino acid-derived N-alkenylurethanes (3) followed by subsequent aminocyclization.