Total synthesis of acetylenic carotenoids-1. Synthesis of optically active 2-E-((4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-enyl)-3-methyl-2 -penten-4-yn- 1-al, a C15-synthon

Article abstract of DOI:10.1016/0957-4166(94)80179-7

The title compound was synthesised in the optically active form in seven steps from (4R,6R)-actinol in 34% overall yield. The relative configuration within the C₁₅-key intermediate acet-ylenic triol, 2-E-5-((1S,4R,6R)-1,4- dihydroxy-2,2,6-trime