First Catalytic and Enantioselective Synthesis of Silyl and Stannyl Substituted Cyclopropylmethanols

Article abstract of DOI:10.1016/0040-4039(94)88221-5

Optically active silyl and stannyl substituted cyclopropylmethanols were effectively obtained by the catalytic and enantioselective cyclopropanation of γ-silyl and γ-stannyl substituted allylic alcohols with Et2Zn and CH2I2 in the presence of chiral N,N'-bis(p-nitrobenzenesulfonyl)-1,2-cyclohexanediamine in good enantioselectivites.The absolute configurations of the resulting metallocyclopropanes were unambiguously established.