Tetrahedron p. 5345 - 5360 (1994)
Update date:2022-07-29
Topics:
Roux, Florence
Maugras, Isabelle
Poncet, Joel
Niel, Gilles
Jouin, Patrick
A stepwise synthesis of dolastatin 10 starting from the dolaphenine residue is described. The chiral dola isoleuine and dolaproine residues were obtained by 5-step procedures from the corresponding N-Boc amino acid. The key steps are respectively the NaBH4 reduction of an allylic ketone and the addition of an achiral Z-crotylboronate on the N-Boc-L-prolinal. Peptidic couplings were efficiently realised with reagents developed in the laboratory.
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Shanghai Yuantai Chemical Products Co., Ltd
Contact:021--66129803
Address:Chengyin Road,Shanghai,China
Shanghai birch chemical technology co.,ltd
Contact:+86-21-54096810
Address:No.2588,Jungong Road,Shanghai,China
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Antaeus Bio-technology Co., LTD(expird)
Contact:021-31252569
Address:shanghai pudong
Doi:10.1016/0040-4039(94)88291-6
(1994)Doi:10.1016/j.ejmech.2014.02.065
(2014)Doi:10.1021/jo500249c
(2014)Doi:10.1016/j.crci.2013.10.004
(2014)Doi:10.1002/anie.201508249
(2016)Doi:10.1021/jm401939g
(2014)
