
Journal of Organic Chemistry p. 7249 - 7258 (1994)
Update date:2022-07-30
Topics: Thioamides Ring Opening Fragmentation Regioselective Semisynthetic
Eberle, Marcel K.
Jutzi-Eme, Anne-Marie
Nuninger, Francois
Cyclosporin A (1a) served as the starting material for the semisynthetic preparation of a variety of novel cyclosporins.Acetylcyclosporin A (2) was treated with Lawesson's reagent.From the reaction mixture, three novel acetylated thioamides were isolated:
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