The chemistry of phosphapeptides: Investigations on the synthesis of phosphonamidate, phosphonate, and phosphinate analogues of glutamyl-γ-glutamate

Article abstract of DOI:10.1021/jo00104a017

The synthesis of the phosphonamidate, 1d, and phosphonate, 1e, analogues of a γ-glutamyl peptide are reported. Michaelis-Albuzov reaction with the alkyl halide, 7b, derived from L-glutamic acid, yielded dimethyl phosphonate, 8b. Selective aminolysis of th